Therapy Detail

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Therapy Name	AZD2936 + Cisplatin + Fluorouracil + Trastuzumab
Synonyms	Rilvegostomig + Trastuzumab + FP
Therapy Description

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
AZD2936		AZD-2936\|AZD 2936\|Rilvegostomig	PD-L1/PD-1 antibody 124 TIGIT Antibody 19	AZD2936 is a bispecific antibody that targets T-cell immunoreceptor with immunoglobulin (Ig) and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT) and PD-1 (PDCD1), which potentially leads to increased T-lymphocyte antitumor activity, tumor cell killing, and inhibition of tumor growth (Journal for ImmunoTherapy of Cancer 2022;10).
Cisplatin	Platinol	CDDP	Chemotherapy - Platinum 7	Platinol (cisplatin) is a platinum based chemotherapeutic, which is FDA approved for bladder, ovarian, and testicular cancers (NCI Drug Dictionary).
Fluorouracil	Adrucil	5-FU\|5-Fluorouracil	Chemotherapy - Antimetabolite 14	Adrucil (fluorouracil) is an antimetabolite chemotherapeutic agent, which interferes with DNA and RNA synthesis thereby preventing cancer cell growth and is FDA approved for colorectal, breast, stomach, and pancreatic cancer (FDA.gov).
Trastuzumab	Herceptin	Anti HER2	HER2 (ERBB2) Antibody 77	Herceptin (trastuzumab) is a monoclonal antibody, which binds ERBB2 (HER2) to induce tumor cellular cytotoxicity (PMID: 17611206). Herceptin (trastuzumab) is FDA approved for HER2-overexpressing (or amplification) breast cancer, gastric adenocarcinoma, and gastroesophageal junction adenocarcinoma (FDA.gov).

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT06764875	Phase III	Capecitabine + Oxaliplatin + Pembrolizumab + Trastuzumab Cisplatin + Fluorouracil + Pembrolizumab + Trastuzumab AZD2936 + Capecitabine + Oxaliplatin + Trastuzumab AZD2936 + Cisplatin + Fluorouracil + Trastuzumab AZD2936 + Fluorouracil + Trastuzumab deruxtecan AZD2936 + Capecitabine + Trastuzumab deruxtecan	A Phase III Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer	Recruiting	USA \| TUR \| POL \| NLD \| ITA \| HUN \| GBR \| FRA \| ESP \| DEU \| CAN \| BRA \| BEL \| AUT \| AUS \| ARG	11

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