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Therapy Name AGEN2373 + Balstilimab + Cyclophosphamide + GVAX
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AGEN2373 AGEN-2373|AGEN 2373 TNFRSF9 Antibody 32 AGEN2373 is a antibody that targets CD137 and acts as an agonist, resulting in increased CD137 signaling and potentially leading to enhanced anti-tumor immune response (Journal of Clinical Oncology 2019 37:15_suppl, e14005).
Balstilimab AGEN-2034|AGEN2034 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 123 Balstilimab (AGEN2034) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 ligand (CD274), potentially resulting in enhanced anti-tumor immune response (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 3086-3086).
Cyclophosphamide Cytoxan CPM Chemotherapy - Alkylating 18 Cytoxan (cyclophosphamide) is an alkylating agent, which inhibits DNA replication (NCI Drug Dictionary). Cytoxan (cyclophosphamide) is FDA approved in multiple hematological malignancies, breast cancer, neuroblastoma, ovarian cancer, and retinoblastoma (NCI Drug Dictionary).
GVAX GVAX is a cancer vaccine derived from irradiated autologous or allogeneic tumor cells engineered to secrete GM-CSF, which potentially stimulates anti-tumor immune response (PMID: 16026242).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06782932 Phase Ib/II AGEN2373 + Balstilimab + Pooled Mutant KRAS-Targeted Long Peptide Vaccine AGEN2373 + Balstilimab + Cyclophosphamide + GVAX Comparing Neoadjuvant/Adjuvant GVAX vs a mKRASvax Given With Anti-PD-1 and Anti-CD137 for Surgically Resectable Pancreatic Cancer Not yet recruiting USA 0


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