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Therapy Name AGEN2373 + Balstilimab + Pooled Mutant KRAS-Targeted Long Peptide Vaccine
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AGEN2373 AGEN-2373|AGEN 2373 TNFRSF9 Antibody 32 AGEN2373 is a antibody that targets CD137 and acts as an agonist, resulting in increased CD137 signaling and potentially leading to enhanced anti-tumor immune response (Journal of Clinical Oncology 2019 37:15_suppl, e14005).
Balstilimab AGEN-2034|AGEN2034 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 123 Balstilimab (AGEN2034) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 ligand (CD274), potentially resulting in enhanced anti-tumor immune response (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 3086-3086).
Pooled Mutant KRAS-Targeted Long Peptide Vaccine KRAS Peptide Vaccine KRAS Inhibitor 19 Pooled mutant KRAS-targeted long peptide vaccine is a mixture of long tumor-specific mutant KRAS peptides, which potentially induces a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing KRAS (NCI Drug Dictionary, Cancer Res (2023) 83 (8_Supplement): CT036).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06782932 Phase Ib/II AGEN2373 + Balstilimab + Pooled Mutant KRAS-Targeted Long Peptide Vaccine AGEN2373 + Balstilimab + Cyclophosphamide + GVAX Comparing Neoadjuvant/Adjuvant GVAX vs a mKRASvax Given With Anti-PD-1 and Anti-CD137 for Surgically Resectable Pancreatic Cancer Not yet recruiting USA 0


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