Therapy Detail
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| Therapy Name | DC myeloma fusion vaccine + Elranatamab-bcmm + Sargramostim |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| DC myeloma fusion vaccine | DC myeloma fusion vaccine is a tumor vaccine developed by fusing patient-specific myeloma cells with autologous dendritic cells, which may enhance anti-tumor immunity (PMID: 21030562, PMID: 23685836). | |||
| Elranatamab-bcmm | Elrexfio | PF-06863135|PF06863135|PF 06863135 | CD3 Antibody 104 TNFRSF17 Antibody 22 | Elrexfio (elranatamab-bcmm) is a bispecific antibody that binds to both TNFRSF17 (BCMA) and CD3, thereby crosslinking BCMA-expressing tumor cells and cytotoxic T-lymphocytes, potentially resulting in increased immune response against BCMA-expressing tumor cells (J Clin Oncol 39, no. 15_suppl (May 20, 2020) 8006-8006). Elrexfio (elranatamab-bcmm) is FDA -approved for use in patients with relapsed or refractory multiple myeloma who have received at least four prior lines of therapy (FDA.gov). |
| Sargramostim | Leukine | GM-CSF|Prokine |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06799026 | Phase I | DC myeloma fusion vaccine + Elranatamab-bcmm + Sargramostim | A Phase 1 Study of Vaccination With Dendritic Cell (DC)/Multiple Myeloma (MM) Fusions in Combination With Elranatamab in Relapsed or Refractory Multiple Myeloma | Not yet recruiting | USA | 0 |
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