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| Drug Name | hALK.CAR T cells |
| Trade Name | |
| Synonyms | |
| Drug Descriptions |
hALK.CAR T cells are T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting ALK linked to the CD8 alpha hinge and transmembrane domain, CD28 costimulatory domain, and CD3zeta signaling domain, which potentially induces cytoxicity against tumor cells with high Alk expression (PMID: 38039964). |
| DrugClasses | |
| CAS Registry Number | NA |
| NCIT ID | NA |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Ceritinib + hALK.CAR T cells | Ceritinib hALK.CAR T cells | 2 | 0 |
| hALK.CAR T cells | hALK.CAR T cells | 4 | 1 |
| hALK.CAR T cells + Lorlatinib | Lorlatinib hALK.CAR T cells | 3 | 0 |
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