Therapy Detail
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| Therapy Name | KK2269 |
| Synonyms | |
| Therapy Description |
KK2269 is a bispecific antibody that targets CD40 expressed on antigen presenting cells (APCs) and EPCAM expressed on tumor cells, resulting in EPCAM-dependent activation of CD40 signaling, which potentially enhances antitumor immune response and delays tumor growth (Cancer Res (2024) 84 (6_Supplement): 5310; Cancer Res (2024) 84 (6_Supplement): 5311). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| KK2269 | KK-2269|KK 2269 | CD40 Antibody 16 | KK2269 is a bispecific antibody that targets CD40 expressed on antigen presenting cells (APCs) and EPCAM expressed on tumor cells, resulting in EPCAM-dependent activation of CD40 signaling, which potentially enhances antitumor immune response and delays tumor growth (Cancer Res (2024) 84 (6_Supplement): 5310; Cancer Res (2024) 84 (6_Supplement): 5311). |
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06266299 | Phase I | Docetaxel + KK2269 KK2269 | A Study of KK2269 in Adult Participants With Solid Tumors | Recruiting | USA | 1 |
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