Therapy Detail
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| Therapy Name | CLSP-1025 |
| Synonyms | |
| Therapy Description |
CLSP-1025 is a bispecific T-cell engager that binds TP53 R175H-mutant peptide bound to HLA-A*2:01 on tumor cells and CD3 on T-cells, which potentially induces T-cell activation (Journal for ImmunoTherapy of Cancer 2024;12: 1061). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| CLSP-1025 | CLSP1025|CLSP 1025 | CD3 Antibody 119 | CLSP-1025 is a bispecific T-cell engager that binds TP53 R175H-mutant peptide bound to HLA-A*2:01 on tumor cells and CD3 on T-cells, which potentially induces T-cell activation (Journal for ImmunoTherapy of Cancer 2024;12: 1061). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06778863 | Phase I | CLSP-1025 | A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation (GUARDIAN-101) | Recruiting | USA | 0 |
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