Therapy Detail
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| Therapy Name | BMS-986504 |
| Synonyms | |
| Therapy Description |
BMS-986504 binds to the PRMT5-MTA complex and inhibits PRMT5 activity, which potentially enhances antitumor immune response and induces killing of tumor cells with deletion of MTAP (Cancer Immunol Res (2024) 12 (10_Supplement): B011, Eur J Cancer 211 (2024): 114537). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BMS-986504 | BMS 986504|BMS986504 | PRMT5 Inhibitor 19 | BMS-986504 binds to the PRMT5-MTA complex and inhibits PRMT5 activity, which potentially enhances antitumor immune response and induces killing of tumor cells with deletion of MTAP (Cancer Immunol Res (2024) 12 (10_Supplement): B011, Eur J Cancer 211 (2024): 114537). |
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06855771 | Phase II | BMS-986504 | A Study of BMS-986504 in Participants With Pre-treated Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With Homozygous MTAP Deletion | Not yet recruiting | USA | ROU | FRA | ESP | DEU | AUS | 1 |
| NCT06672523 | Phase I | BMS-986504 | A Study to Evaluate the Mass Balance, Metabolism, Elimination, and Drug Levels of [14C]-BMS-986504 (MRTX1719) in Participants With Advanced Solid Tumors With Homozygous Methylthioadenosine Phosphorylase Deletion | Not yet recruiting | HUN | 0 |
| NCT06883747 | Phase I | BMS-986504 | Clinical Trial of BMS-986504 in Recurrent GBM Patients | Not yet recruiting | USA | 0 |
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