Therapy Detail
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| Therapy Name | Allostim + Avelumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Allostim | Allostim is a preparation of allogeneic CD4-positive Th1-like T-cells bound to microparticles coated with anti-CD3 and anti-CD28 antibodies, which potentially induces antitumor immune response (NCI Thesaurus, J Clin Oncol 2025 43:4_suppl, TPS318). | |||
| Avelumab | Bavencio | MSB0010718C | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 124 | Bavencio (avelumab) is a monoclonal antibody binds to human immunosuppressive ligand programmed death-ligand 1 (PD-L1, CD274) and blocks protein signaling, resulting in immune regulation and antitumor immunity (PMID: 26014098). Bavencio (avelumab) is FDA-approved for use in adult and pediatric patients of 12 years or older with metastatic Merkel cell carcinoma, as maintenance therapy in locally advanced or metastatic urothelial carcinoma (UC), in locally advanced or metastatic UC that progressed following chemotherapy, and in combination with axitinib as first-line therapy in advanced renal cell carcinoma (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06557278 | Phase II | Allostim + Avelumab | Combined AlloStim+Anti-PD-L1 in MSS Metastatic Colorectal Cancer (COMUNITY) | Not yet recruiting | USA | 0 |
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