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| Therapy Name | BCG solution + Intismeran autogene |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BCG solution | TICE BCG solution | Bacillus Calmette-Guerin solution | TICE BCG solution (BCG solution) is an attenuated live culture of Bacillus Calmette Guerin that induces anti-tumor immunity in bladder cancer (PMID: 26000263). TICE BCG solution (BCG solution) is FDA approved for carcinoma in situ of the bladder (FDA.gov). | |
| Intismeran autogene | mRNA4157|mRNA 4157|V940|V-940|V 940|mRNA-4157 | Intismeran autogene (mRNA-4157) is an mRNA-based lipid encapsulated personalized cancer vaccine encoding specific neoantigens, which potentially leads to enhanced anti-tumor immune response (Journal for ImmunoTherapy of Cancer 2020;8). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06833073 | Phase II | Intismeran autogene BCG solution + Intismeran autogene BCG solution | A Clinical Study of V940 and BCG in People With Bladder Cancer (V940-011/INTerpath-011) | Recruiting | USA | POL | NLD | ITA | HUN | GRC | GBR | FRA | ESP | DNK | DEU | CAN | BRA | AUS | ARG | 3 |
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