Therapy Detail
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| Therapy Name | ASP3082 + Gemcitabine + Nab-paclitaxel |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ASP3082 | ASP 3082|ASP-3082 | KRAS G12D Inhibitor 18 | ASP3082 degrades KRAS G12D, potentially leading to decreased Erk phosphorylation and inhibition of cell growth and tumor regression (European Journal of Cancer 174 (2022): S30). | |
| Gemcitabine | Gemzar | Difluorodeoxycytidine Hydrochlorothiazide|LY-188011 | Chemotherapy - Antimetabolite 14 | Gemzar (gemcitabine) is converted in cells to difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP), which act to inhibit ribonucleoside reductase and as a deoxynucleotide analog respectively, resulting in DNA strand termination and apoptosis (NCI Drug Dictionary). |
| Nab-paclitaxel | Abraxane | ABI-007|Paclitaxel Protein-bound | Chemotherapy - Taxane 3 | Abraxane (nab-paclitaxel) is an albumin-stablized version of paclitaxel, which binds microtubules and prevents depolymerization, resulting in decreased cell motility and division (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05382559 | Phase I | ASP3082 + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin ASP3082 ASP3082 + Gemcitabine + Nab-paclitaxel ASP3082 + Cetuximab | A Study of ASP3082 in Adults With Advanced Solid Tumors | Recruiting | USA | FRA | ESP | 2 |
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