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Therapy Name ASP3082 + Cisplatin + Pembrolizumab + Pemetrexed Disodium
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ASP3082 ASP 3082|ASP-3082 KRAS G12D Inhibitor 25 ASP3082 degrades KRAS G12D, potentially leading to decreased Erk phosphorylation and inhibition of cell growth and tumor regression (European Journal of Cancer 174 (2022): S30).
Cisplatin Platinol CDDP Chemotherapy - Platinum 7 Platinol (cisplatin) is a platinum based chemotherapeutic, which is FDA approved for bladder, ovarian, and testicular cancers (NCI Drug Dictionary).
Pembrolizumab Keytruda MK-3475 Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 136 Keytruda (pembrolizumab) is an antibody against PD-1 that activates T-cell mediated anti-tumor immune response (PMID: 25977344). Keytruda (pembrolizumab) is approved in melanoma, SCLC, HNSCC, classical Hodgkin Lymphoma, PMBL, urothelial carcinoma, HCC, Merkel cell carcinoma, NMIBC, cutaneous SCC, MSI-H or dMMR or TMB high advanced solid tumors, NSCLC and CD274 (PD-L1)-positive NSCLC, esophageal SCC, cervical cancer, HNSCC, and TNBC, in combination with platnum-based chemo in NSCLC, with pemetrexed and platinum in pleural mesothelioma and non-sNSCLC with no EGFR or ALK mutations, with carboplatin and paclitaxel/nab-paclitaxel in sNSCLC, with axitinib or lenvatinib in RCC, with lenvatinib in endometrial carcinoma that is not MSI-H or dMMR, with platinum and fluoropyrimidine-based chemo for esophageal or gastroesophageal carcinoma, with Herceptin (trastuzumab), fluoropyrimidine- and platinum-containing chemo for CD274 (PD-L1)-positive, HER2-positive gastric or GEJ adenocarcinoma, with fluoropyrimidine- and platinum-containing chemo for HER2-negative gastric or GEJ adenocarcinoma, with platinum-based chemotherapy, with or without bevacizumab, for patients with CD274 (PD-L1)-positive cervical cancer, with gemcitabine and cisplatin for biliary tract cancer, with chemoradiation for cervical cancer, with carboplatin and paclitaxel for endometrial carcinoma, with paclitaxel with or without bevacizumab for epithelial ovarian, Fallopian tube, and peritonium cancer (FDA.gov).
Pemetrexed Disodium Alimta LY231514|Ciambra|pemetrexed Chemotherapy - Antimetabolite 14 Alimta (pemetrexed disodium) is an antifolate that inhibits thymidylate synthase (NCI Drug Dictionary).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05382559 Phase I ASP3082 + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin ASP3082 ASP3082 + Pembrolizumab ASP3082 + Cisplatin + Pemetrexed Disodium ASP3082 + Gemcitabine + Nab-paclitaxel ASP3082 + Carboplatin + Pemetrexed Disodium ASP3082 + Cisplatin + Pembrolizumab + Pemetrexed Disodium ASP3082 + Cetuximab ASP3082 + Carboplatin + Pembrolizumab + Pemetrexed Disodium A Study of ASP3082 in Adults With Advanced Solid Tumors Recruiting USA | FRA | ESP 3


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