Therapy Detail
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| Therapy Name | Bria-OTS + Cyclophosphamide + Peginterferon alfa-2b + Tislelizumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Bria-OTS | Bria-OTS comprises a cancer cell line engineered to carry multiple HLA alleles and express a costimulatory molecule (CD80, CD86, or CD40) and immunomodulatory cytokine (GM-CSF, IFNalpha, IL-12, or IL-7), which potentially enhances antitumor immune response (Cancer Res 2023;83(7_Suppl):Abstract nr 685). | |||
| Cyclophosphamide | Cytoxan | CPM | Chemotherapy - Alkylating 18 | Cytoxan (cyclophosphamide) is an alkylating agent, which inhibits DNA replication (NCI Drug Dictionary). Cytoxan (cyclophosphamide) is FDA approved in multiple hematological malignancies, breast cancer, neuroblastoma, ovarian cancer, and retinoblastoma (NCI Drug Dictionary). |
| Peginterferon alfa-2b | Sylatron | PEG-IFN | Sylatron (peginterferon alfa-2b) is polyethylene glycol (PEG)-conjugated recombinant interferon alpha, subtype 2b, which may have antitumor activity (PMID: 23002124, PMID: 16953837, PMID: 24741445). | |
| Tislelizumab | Tevimbra | BGB-A317|tislelizumab-jsgr | Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 132 | Tevimbra (tislelizumab) is a human monoclonal antibody that targets PD-1 (PDCD1), thereby blocking the binding of PD-L1 (CD274) and potentially resulting in activation of a T-cell immune response against tumor cells (PMID: 32769013, PMID: 32561638, PMID: 32540858). Tevimbra (tislelizumab) is FDA-approved for use in patients with unresectable or metastatic esophageal squamous cell carcinoma (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06471673 | Phase Ib/II | Bria-OTS Bria-OTS + Cyclophosphamide + Peginterferon alfa-2b + Tislelizumab | A Study of BRIA-OTS Cellular Immunotherapy in Metastatic Recurrent Breast Cancer | Recruiting | USA | 0 |
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