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Therapy Name Asparaginase Erwinia chrysanthemi + Cyclophosphamide + Cytarabine + Mercaptopurine + Methotrexate + Vincristine Sulfate
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Asparaginase Erwinia chrysanthemi Erwinaze Crisantaspase|JZP458|JZP-458|JZP 458|Rylaze|PF743|RC-P JZP-458 Erwinaze (asparaginase Erwinia chrysanthemi) is an bacterial derived enzyme that converts L-asparagine to L-aspartate and ammonia, which decreases L-asparagine levels, potentially leading to reduced leukemic cell growth (PMID: 25098829, PMID: 26698391). Erwinaze (asparaginase Erwinia chrysanthemi) is FDA-approved for use in a chemotherapeutic regimen for acute lymphoblastic leukemia (FDA.gov).
Cyclophosphamide Cytoxan CPM Chemotherapy - Alkylating 18 Cytoxan (cyclophosphamide) is an alkylating agent, which inhibits DNA replication (NCI Drug Dictionary). Cytoxan (cyclophosphamide) is FDA approved in multiple hematological malignancies, breast cancer, neuroblastoma, ovarian cancer, and retinoblastoma (NCI Drug Dictionary).
Cytarabine Cytosar-U Ara-C Cytosar-U (cytarabine) is a cytidine analog that, when incorporated into DNA, inhibits DNA synthesis and repair (PMID: 32524309).
Mercaptopurine Purixan 6 MP|Purinethol
Methotrexate Abitrexate Amethopterin Chemotherapy - Antimetabolite 14 Methotrexate is an antimetabolite, which inhibits DHFR resulting in decreased immune function and antineoplastic activity and is FDA approved for psoriasis, RA, and several cancers including choriocarcinoma, AML, lung, head and neck and epidermoid (FDA.gov).
Vincristine Sulfate Oncovin 22-Oxovincaleukoblastine|vincristine Oncovin (vincristine) binds microtubules and prevents mitotic spindle formation, resulting in cell-cycle arrest (NCI Drug Dictionary).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06918431 Phase II Asparaginase Erwinia chrysanthemi + Daunorubicin + Dexamethasone + Methotrexate + Rituximab + Vincristine Sulfate Asparaginase Erwinia chrysanthemi + Cyclophosphamide + Cytarabine + Mercaptopurine + Methotrexate + Vincristine Sulfate Asparaginase Erwinia chrysanthemi + Daunorubicin + Dexamethasone + Vincristine Sulfate Asparaginase Erwinia chrysanthemi + Daunorubicin + Dexamethasone + Methotrexate + Vincristine Sulfate Asparaginase Erwinia Chrysanthemi With Chemotherapy for the Treatment of High-Risk Adults With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Recruiting USA 0


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