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Drug Name | Asparaginase Erwinia chrysanthemi |
Trade Name | Erwinaze |
Synonyms | Crisantaspase |
Drug Descriptions |
Erwinaze (asparaginase Erwinia chrysanthemi) is an bacterial derived enzyme that converts L-asparagine to L-aspartate and ammonia, which decreases L-asparagine levels, potentially leading to reduced leukemic cell growth (PMID: 25098829, PMID: 26698391). Erwinaze (asparaginase Erwinia chrysanthemi) is FDA-approved for use in a chemotherapeutic regimen for acute lymphoblastic leukemia (FDA.gov). |
DrugClasses | |
CAS Registry Number | 9015-68-3 |
NCIT ID | C64260 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Asparaginase Erwinia chrysanthemi | Asparaginase Erwinia chrysanthemi | 0 | 2 |
Asparaginase Erwinia chrysanthemi + Cytarabine | Asparaginase Erwinia chrysanthemi Cytarabine | 0 | 1 |
Asparaginase Erwinia chrysanthemi + Cytarabine + Sorafenib | Asparaginase Erwinia chrysanthemi Cytarabine Sorafenib | 0 | 1 |