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Therapy Name | MSGV1-PSCA-8T28Z |
Synonyms | |
Therapy Description |
MSGV1-PSCA-8T28Z are autologous gamma delta T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting PSCA, containing a CD8 alpha hinge and transmembrane domain, CD28 costimulatory domain, and CD3zeta signaling domain, which potentially induce cytotoxicity against PSCA-expressing tumor cells and inhibit tumor growth (PMID: 37134157). |