Therapy Detail
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| Therapy Name | BNT327 + DB-1311 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BNT327 | PM8002|Pumitamig|BNT-327|BNT 327|BM-8002 | PD-L1/PD-1 antibody 133 VEGFA Antibody 5 | BNT327 (PM8002) is a bispecific antibody that targets VEGFA and PD-L1 (CD274), which potentially induces antitumor activity (J Clin Oncol 42, no. 16_suppl (May 29, 2024) 5524). | |
| DB-1311 | DB 1311|DB1311|BNT324|BNT-324|BNT 324 | CD276 Antibody 21 | DB-1311 is an antibody-drug conjugate (ADC) comprising a B7-H3 (CD276) antibody conjugated to the topoisomerase inhibitor P1021, which potentially decreases growth of B7-H3 (CD276)-expressing tumors (Cancer Res (2023) 83 (7_Supplement): 2967). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06892548 | Phase Ib/II | BNT327 + DB-1311 | A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer | Recruiting | USA | TUR | GBR | AUS | 1 |
| NCT06953089 | Phase II | DB-1305 + DB-1311 BNT327 + DB-1311 | DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors | Recruiting | USA | AUS | 2 |
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