Therapy Detail
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| Therapy Name | Cosibelimab + POL6326 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Cosibelimab | Unloxcyt | CK-301|CK 301|TG-1501|TG1501|TG 1501|cosibelimab-ipdl | Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 132 | Unloxcyt (cosibelimab) is a human monoclonal antibody against PD-L1 (CD274), which may block immune checkpoint, and lead to anti-tumor immune response (PMID: 37848259). Unloxcyt (cosibelimab) is FDA approved for use in adult patients with metastatic or locally advanced cutaneous squamous cell carcinoma who are not candidates for curative surgery or curative radiation (FDA.gov). |
| POL6326 | Balixafortide | CXCR4 Inhibitor 15 | Balixafortide (POL6326) binds to CXCR4 and inhibits SDF-1 (CXCL12) binding, potentially resulting in increased mobilization of hematopoietic cells (PMID: 29706375). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06981806 | Phase I | Cosibelimab + POL6326 | Phase I Study of Cosibelimab and Balixafortide in Metastatic Pancreatic Ductal Adenocarcinoma | Not yet recruiting | USA | 0 |
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