Therapy Detail
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| Therapy Name | Decitabine and Cedazuridine + SM08502 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Decitabine and Cedazuridine | Inqovi | ASTX-727|ASTX 727|ASTX727 | Chemotherapy - Antimetabolite 14 | Inqovi (decitabine and cedazuridine) is a combination of decitabine and cedazuridine, which may inhibit proliferation of tumor cells (PMID: 30926081). Inqovi (decitabine and cedazuridine) is an FDA approved chemotherapy agent (FDA.gov). |
| SM08502 | SM-08502|SM 08502|Cirtuvivint | WNT Inhibitor 17 | SM08502 is a small molecule inhibitor of Wnt signaling that inhibits CDC-like kinase (CLK), potentially resulting in decreased tumor cell proliferation (PMID: 31560935, PMID: 39258426). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06484062 | Phase I | SM08502 Decitabine and Cedazuridine + SM08502 | Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes | Recruiting | USA | 0 |
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