Therapy Detail
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| Therapy Name | AZD0171 + Durvalumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AZD0171 | AZD 0171|AZD-0171 | AZD0171 is a monoclonal antibody that targets leukemic inhibitory factor (LIF), leading to decreased downstream signaling, potentially resulting in antitumor activity (Cancer Res 2022;82(12_Suppl):Abstract nr 1293). | ||
| Durvalumab | Imfinzi | MEDI4736 | Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 132 | Imfinzi (durvalumab) is a monoclonal antibody that binds to and inhibits PD-L1 (CD274), potentially resulting in increased immune response to tumors (PMID: 25943534, PMID: 28214651). Imfinzi (durvalumab) is FDA-approved for use in patients with unresectable, stage III non-small cell lung cancer, and limited-stage small cell lung cancer, in combination with Imjudo (tremelimumab) and platinum-based chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC) without sensitizing EGFR or ALK mutations, in combination with platinum-based chemotherapy as neoadjuvant therapy followed by surgery and adjuvant Imfinzi (durvalumab) in patients with resectable non-small cell lung cancer, in combination with etoposide and carboplatin or cisplatin in patients with extensive stage small cell lung cancer, in combination with cisplatin and gemcitabine in patients with locally advanced or metastatic biliary tract cancer, in combination with Imjudo (tremelimumab) in adult patients with unresectable hepatocellular carcinoma, in combination with carboplatin plus paclitaxel followed by single-agent Imfinzi (durvalumab) in adult patients with mismatch repair deficient endometrial cancer, in combination with cisplatin plus gemcitabine followed by single-agent Imfinzi (durvalumab) in adult patients with muscle invasive bladder cancer (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05061550 | Phase II | Durvalumab + Monalizumab Datopotamab deruxtecan + Durvalumab AZD0171 + Durvalumab Durvalumab + Oleclumab AZD2936 AZD2936 + Datopotamab deruxtecan MEDI5752 | Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer (NeoCOAST-2) | Recruiting | USA | TUR | ITA | IRL | HUN | FRA | ESP | CAN | BEL | 3 |
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