Therapy Detail
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| Therapy Name | MEDI5752 |
| Synonyms | |
| Therapy Description |
MEDI5752 is a bispecific human IgG1 monoclonal antibody that binds PD1 (PDCD1) and CTLA4, potentially resulting in enhanced anti-tumor immune response (Cancer Res 2018;78(13 Suppl):Abstract nr 2776). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| MEDI5752 | MEDI-5752|MEDI 5752|volrustomig | CTLA4 Antibody 33 Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 132 | MEDI5752 is a bispecific human IgG1 monoclonal antibody that binds PD1 (PDCD1) and CTLA4, potentially resulting in enhanced anti-tumor immune response (Cancer Res 2018;78(13 Suppl):Abstract nr 2776). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06079671 | Phase III | MEDI5752 | Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer (eVOLVE-Cervical) (eVOLVECervical) | Recruiting | USA | TUR | POL | NOR | ITA | ESP | DNK | DEU | CAN | BRA | 9 |
| NCT07065630 | Phase II | Carboplatin Paclitaxel MEDI5752 | Response-Adaptive Treatment in Untreated Locoregional HPV-Negative Head and Neck Cancer | Not yet recruiting | USA | 0 |
| NCT03530397 | Phase I | Carboplatin + Pembrolizumab + Pemetrexed Disodium Durvalumab Carboplatin + MEDI5752 + Pemetrexed Disodium MEDI5752 | A Study to Evaluate MEDI5752 in Subjects With Advanced Solid Tumors | Active, not recruiting | USA | NLD | ITA | FRA | ESP | AUS | 3 |
| NCT06535607 | Phase II | MEDI5752 Carboplatin + MEDI5752 + Paclitaxel Carboplatin + Fluorouracil + MEDI5752 Cisplatin + Fluorouracil + MEDI5752 | Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors (eVOLVE-02) | Recruiting | USA | BRA | 4 |
| NCT06129864 | Phase III | MEDI5752 | A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy (eVOLVE-HNSCC) | Recruiting | USA | TUR | POL | ITA | HUN | GBR | FRA | ESP | DEU | CAN | BRA | BEL | AUT | 10 |
| NCT05775159 | Phase II | Lenvatinib + MEDI5752 Bevacizumab + MEDI5752 MEDI5752 | Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer | Recruiting | USA | ITA | GBR | ESP | 5 |
| NCT06366451 | Phase I | AZD2936 Pembrolizumab AZD7789 MEDI5752 | PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, and Sabestomig in HNSCC | Recruiting | USA | 0 |
| NCT05061550 | Phase II | Durvalumab + Monalizumab Datopotamab deruxtecan + Durvalumab AZD0171 + Durvalumab Durvalumab + Oleclumab AZD2936 AZD2936 + Datopotamab deruxtecan MEDI5752 | Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer (NeoCOAST-2) | Recruiting | USA | TUR | ITA | IRL | HUN | FRA | ESP | CAN | BEL | 3 |
| NCT07000149 | Phase III | AB521 + MEDI5752 Ipilimumab + Nivolumab MEDI5752 | A Study to Investigate the Efficacy and Safety of Volrustomig ± Casdatifan vs Nivolumab + Ipilimumab as 1L Treatment for Advanced ccRCC (eVOLVE-RCC02) | Active, not recruiting | USA | AUS | 4 |
| NCT05821231 | Phase I | MEDI5752 | Study Evaluating the Safety and Efficacy of MEDI5752 in Combination With Stereotactic Radiotherapy in Patients With Metastatic Sarcoma (MEDISARC-SBRT) | Active, not recruiting | FRA | 0 |
| NCT05888857 | Phase II | MEDI5752 | A Multicentric Phase II Trial Evaluating MEDI5752 in Patients With Mature Tertiary Lymphoid Structures Solid Tumors. (TAYLOR) | Not yet recruiting | FRA | 0 |
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