Therapy Detail
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| Therapy Name | Fulvestrant + PF-07220060 + PF-07248144 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Fulvestrant | Faslodex | ICI 182,780 | Hormone - Anti-estrogens 31 | Faslodex (fulvestrant) is a competitive inhibitor of estrogen that binds and deforms estrogen receptors, and causes inhibition of growth in cultured estrogen-sensitive breast cancer cells and is FDA approved for use in patients with hormone receptor-positive breast cancer (FDA.gov). |
| PF-07220060 | PF 07220060|PF07220060|Atirmociclib | CDK4 Inhibitor 18 | PF-07220060 inhibits CDK4 and may lead to cell cycle arrest and inhibition of tumor cell proliferation (NCI Drug Dictionary). | |
| PF-07248144 | PF07248144|PF 07248144 | PF-07248144 selectively inhibits KAT6, a histone acetyltransferase regulating gene expression, which may lead to tumor growth inhibition (J Clin Oncol 41, 2023 (suppl 16; abstr 1054)). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04606446 | Phase I | PF-07248144 PF-07248144 + Vepdegestrant Fulvestrant + PF-07220060 + PF-07248144 Fulvestrant + Palbociclib + PF-07248144 Fulvestrant + PF-07248144 Letrozole + Palbociclib + PF-07248144 | Study of PF-07248144 in Advanced or Metastatic Solid Tumors (KAT6) | Recruiting | USA | AUS | 3 |
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