Therapy Detail
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| Therapy Name | PF-07248144 + Vepdegestrant |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| PF-07248144 | PF07248144|PF 07248144 | PF-07248144 selectively inhibits KAT6, a histone acetyltransferase regulating gene expression, which may lead to tumor growth inhibition (J Clin Oncol 41, 2023 (suppl 16; abstr 1054)). | ||
| Vepdegestrant | ARV471|ARV 471|PF 07850327|PF07850327|PF-07850327|ARV-471 | Hormone - Anti-estrogens 31 | Vepdegestrant (ARV-471) is a bifunctional molecule that targets the estrogen receptor (ESR1), including ESR1 variants, for proteolytic degradation resulting in reduced target gene expression and potentially leading to reduced cell proliferation and inhibition of tumor growth (Cancer Res 2019;79(4 Suppl):Abstract nr P5-04-18, PMID: 32829249). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04606446 | Phase I | PF-07248144 PF-07248144 + Vepdegestrant Fulvestrant + PF-07220060 + PF-07248144 Fulvestrant + Palbociclib + PF-07248144 Fulvestrant + PF-07248144 Letrozole + Palbociclib + PF-07248144 | Study of PF-07248144 in Advanced or Metastatic Solid Tumors (KAT6) | Recruiting | USA | AUS | 3 |
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