Therapy Detail
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| Therapy Name | PLB1004 + Vebreltinib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| PLB1004 | PLB 1004|PLB-1004 | EGFR Exon 20 Insertion Inhibitor 15 EGFR Inhibitor (Pan) 63 | PLB1004 is an EGFR inhibitor with activity against L858R, T790M, exon 19 deletions, and exon 20 insertion mutations, which potentially decreases tumor growth (Cancer Res (2023) 83 (8_Supplement): CT102). | |
| Vebreltinib | Bozitinib|PLB1001|PLB-1001|APL-101|APL 101|APL101 | MET Inhibitor 59 | Vebreltinib (PLB-1001) is an ATP-competitive, small molecule inhibitor of MET, which is able to permeate the blood brain barrier and may inhibit downstream signaling and block tumor growth (PMID: 30343896). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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