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Therapy Name TGFBR2 KO CAR27/IL-15 NK cells
Synonyms
Therapy Description

TGFBR2 KO CAR27/IL-15 NK cells are allogeneic natural killer cells engineered to express a chimeric antigen receptor (CAR) targeting CD70, to express IL-15, and with TGFBR2 deletion, which potentially induce cytotoxicity in tumor cells expressing CD70 (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
TGFBR2 KO CAR27/IL-15 NK cells Allogeneic TGFBR2 KO CAR27/IL-15-expressing NK cells CD70 Immune Cell Therapy 11 TGFBR2 KO CAR27/IL-15 NK cells are allogeneic natural killer cells engineered to express a chimeric antigen receptor (CAR) targeting CD70, to express IL-15, and with TGFBR2 deletion, which potentially induce cytotoxicity in tumor cells expressing CD70 (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06930651 Phase Ib/II Cyclophosphamide + Decitabine + Dexamethasone + Fludarabine TGFBR2 KO CAR27/IL-15 NK cells A Phase I/II Study of CAR.70-Engineered IL15-Transduced Cord Blood-Derived NK Cells With TGF-beta Receptor 2 (TGFBR2) Knock Out in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapsed/Refractory Myeloid Malignancies Recruiting USA 0


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