Therapy Detail
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| Therapy Name | Cladribine + Cytarabine + Filgrastim + Lintuzumab-Ac225 + Mitoxantrone |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Cladribine | Leustatin | 2-CdA | Leustatin (cladribine) is a purine analog that is incorporated into DNA, resulting in DNA single strand breaks and apoptosis (NCI Drug Dictionary). | |
| Cytarabine | Cytosar-U | Ara-C | Cytosar-U (cytarabine) is a cytidine analog that, when incorporated into DNA, inhibits DNA synthesis and repair (PMID: 32524309). | |
| Filgrastim | Neupogen | G-CSF | Neupogen (filgrastim) is a recombinant analog of granulocyte colony-stimulating factor (G-CSF) isoform B, which binds and activates G-CSF receptors modulating neutrophilic granulocyte progenitor activity, production, and differentiation (NCI Drug Dictionary). | |
| Lintuzumab-Ac225 | HuM195-Ac225|Actimab-A|Actinium Ac 225 Lintuzumab | CD33 Antibody 17 | Lintuzumab-Ac225 is an anti-CD33 antibody in conjugation with a radioactive isotope (225Ac) that has anti-leukemia activity (PMID: 24857092). | |
| Mitoxantrone | Novantrone | CL 232315 | TOPO2 inhibitor 5 | Novantrone (mitoxantrone) binds to and inhibits topoisomerase II, leading to DNA double strand breaks and decreased DNA repair (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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