Therapy Detail
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| Therapy Name | OPB-101 |
| Synonyms | |
| Therapy Description |
OPB-101 comprises T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting MSLN, in addition to a novel promoter, safety switch, and a CD8alpha-targeted IL-2/15 cytokine, which potentially induces killing of MSLN-expressing tumor cells and inhibits tumor growth (Cancer Res (2024) 84 (6_Supplement): 51). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| OPB-101 | OPB101|OPB 101 | MSLN Immune Cell Therapy 10 | OPB-101 comprises T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting MSLN, in addition to a novel promoter, safety switch, and a CD8alpha-targeted IL-2/15 cytokine, which potentially induces killing of MSLN-expressing tumor cells and inhibits tumor growth (Cancer Res (2024) 84 (6_Supplement): 51). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07030907 | Phase I | OPB-101 | A Study to Evaluate the Safety and Efficacy of OPB-101 in Platinum-resistant Ovarian Cancer | Recruiting | USA | 0 |
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