Therapy Detail
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| Therapy Name | Pegylated liposomal doxorubicin + Sargramostim + STEMVAC |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Pegylated liposomal doxorubicin | Doxil | ATI-0918|CAELYX|liposomal doxorubicin | Chemotherapy - Anthracycline 13 | Doxil (pegylated liposomal doxorubicin) comprises the anthracyline doxorubicin, which intercalates into DNA and disrupts DNA replication, encapsulated in a liposome, which improves tumor penetration and decreases toxicity (NCI Drug Dictionary), and is FDA approved for ovarian cancer, AIDS-related Kaposi's sarcoma, and multiple myeloma (FDA.gov). |
| STEMVAC | CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope plasmid DNA vaccine | STEMVAC is a cancer vaccine that encodes multiple class II epitopes that result in a Th1 response upon expression, potentially leading to enhanced antitumor immune response (Journal for ImmunoTherapy of Cancer 2022;10, NCI Drug Dictionary). | ||
| Sargramostim | Leukine | GM-CSF|Prokine |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07078604 | Phase II | Docetaxel + Sargramostim + STEMVAC Paclitaxel + Sargramostim + STEMVAC Carboplatin + Sargramostim + STEMVAC Doxorubicin + Sargramostim + STEMVAC Cisplatin + Sargramostim + STEMVAC Eribulin + Sargramostim + STEMVAC Pegylated liposomal doxorubicin + Sargramostim + STEMVAC | A Cancer Vaccine (STEMVAC) in Combination With Chemotherapy for the Treatment of PD-L1 Negative Metastatic Triple-Negative Breast Cancer | Not yet recruiting | USA | 0 |
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