Therapy Detail
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| Therapy Name | M0324 |
| Synonyms | |
| Therapy Description |
M0324 is a MUC1-conditional CD40 agonist comprising an antibody targeting MUC1 and two heavy-chain variable domains that bind to CD40, which potentially induces antitumor immune activity against MUC1-expressing tumors (Cancer Res (2025) 85 (8_Supplement_2): ND12). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| M0324 | M-0324|M 0324 | CD40 Antibody 16 MUC1 Antibody 8 | M0324 is a MUC1-conditional CD40 agonist comprising an antibody targeting MUC1 and two heavy-chain variable domains that bind to CD40, which potentially induces antitumor immune activity against MUC1-expressing tumors (Cancer Res (2025) 85 (8_Supplement_2): ND12). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07166601 | Phase I | M0324 + Pembrolizumab Fluorouracil + Irinotecan + Leucovorin + M0324 + Oxaliplatin M0324 | M0324 as Monotherapy and in Combination With Pembrolizumab or Chemotherapy in Participants With Selected Advanced Solid Tumors (TITER) | Recruiting | USA | CAN | 1 |
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