Therapy Detail
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| Therapy Name | B7H3 CAR-T cells |
| Synonyms | |
| Therapy Description |
B7H3 CAR-T cells are T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting CD276 (B7-H3) linked to a CD137 (4-1BB) co-stimulatory motif and a CD3zeta signaling domain, which potentially inhibit tumor growth (PMID: 30655315, J Clin Oncol 2025 43: 16_suppl, 2018). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| B7H3 CAR-T cells | CD276 Immune Cell Therapy 10 | B7H3 CAR-T cells are T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting CD276 (B7-H3) linked to a CD137 (4-1BB) co-stimulatory motif and a CD3zeta signaling domain, which potentially inhibit tumor growth (PMID: 30655315, J Clin Oncol 2025 43: 16_suppl, 2018). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06500819 | Phase I | B7H3 CAR-T cells | Autologous B7-H3 Chimeric Antigen Receptor T Cells in Relapsed/Refractory Solid Tumors | Recruiting | USA | 0 |
| NCT06646627 | Phase I | B7H3 CAR-T cells | Clinical Trial of Autologous B7-H3 CAR T Cells in Reoccurent Platinum-resistant Ovarian Tumors | Recruiting | USA | 0 |
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