Therapy Detail
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| Therapy Name | YL242 |
| Synonyms | |
| Therapy Description |
YL242 is a non-internalized antibody-drug conjugate (ADC) comprising a VEGF antibody linked to a DNA topoisomerase I inhibitor by a protease-cleavable tripeptide that is cleaved in the tumor microenvironment, which potentially induces cytotoxicity in tumor cells and inhibits tumor growth (Cancer Res (2025) 85 (8_Supplement_1): 3140). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| YL242 | YL-242|YL 242 | VEGF Antibody 15 | YL242 is a non-internalized antibody-drug conjugate (ADC) comprising a VEGF antibody linked to a DNA topoisomerase I inhibitor by a protease-cleavable tripeptide that is cleaved in the tumor microenvironment, which potentially induces cytotoxicity in tumor cells and inhibits tumor growth (Cancer Res (2025) 85 (8_Supplement_1): 3140). |
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07197827 | Phase Ib/II | Pembrolizumab + YL242 Fluorouracil + Pembrolizumab + YL242 Fluorouracil + Leucovorin + YL242 YL242 | A Study of YL242 in Subjects With Advanced Solid Tumors | Recruiting | USA | AUS | 1 |
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