Therapy Detail
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| Therapy Name | Fluorouracil + Leucovorin + YL242 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Fluorouracil | Adrucil | 5-FU|5-Fluorouracil | Chemotherapy - Antimetabolite 14 | Adrucil (fluorouracil) is an antimetabolite chemotherapeutic agent, which interferes with DNA and RNA synthesis thereby preventing cancer cell growth and is FDA approved for colorectal, breast, stomach, and pancreatic cancer (FDA.gov). |
| Leucovorin | Wellcovorin | Calcium folinate|Calcium citrovorum factor|folinic acid | Chemotherapy - Antimetabolite 14 | Wellcovorin (leucovorin) is a metabolite of folate that enhances the efficacy of fluoruracil (PMID: 32490554). |
| YL242 | YL-242|YL 242 | VEGF Antibody 15 | YL242 is a non-internalized antibody-drug conjugate (ADC) comprising a VEGF antibody linked to a DNA topoisomerase I inhibitor by a protease-cleavable tripeptide that is cleaved in the tumor microenvironment, which potentially induces cytotoxicity in tumor cells and inhibits tumor growth (Cancer Res (2025) 85 (8_Supplement_1): 3140). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07197827 | Phase Ib/II | Pembrolizumab + YL242 Fluorouracil + Pembrolizumab + YL242 Fluorouracil + Leucovorin + YL242 YL242 | A Study of YL242 in Subjects With Advanced Solid Tumors | Recruiting | USA | AUS | 1 |
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