Therapy Detail
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| Therapy Name | Fluorouracil + Leucovorin + YL242 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Fluorouracil | Adrucil | 5-FU|5-Fluorouracil | Chemotherapy - Antimetabolite 14 | Adrucil (fluorouracil) is an antimetabolite chemotherapeutic agent that interferes with DNA and RNA synthesis, thereby preventing cancer cell growth (PMID: 28520376). Adrucil (fluorouracil) is FDA-approved for use in patients with adenocarcinoma of the colon, rectum, breast, stomach, and pancreas (FDA.gov). |
| Leucovorin | Wellcovorin | Calcium folinate|Calcium citrovorum factor|folinic acid | Chemotherapy - Antimetabolite 14 | Wellcovorin (leucovorin) is a metabolite of folate that enhances the efficacy of fluoruracil (PMID: 32490554). |
| YL242 | YL-242|YL 242 | VEGF Antibody 17 | YL242 is a non-internalized antibody-drug conjugate (ADC) comprising a VEGF antibody linked to a DNA topoisomerase I inhibitor by a protease-cleavable tripeptide that is cleaved in the tumor microenvironment, which potentially induces cytotoxicity in tumor cells and inhibits tumor growth (Cancer Res (2025) 85 (8_Supplement_1): 3140). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07197827 | Phase Ib/II | Pembrolizumab + YL242 Fluorouracil + Pembrolizumab + YL242 Fluorouracil + Leucovorin + YL242 YL242 | A Study of YL242 in Subjects With Advanced Solid Tumors | Recruiting | USA | AUS | 1 |
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