Therapy Detail
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| Therapy Name | Gemcitabine + Nab-paclitaxel + VS-7375 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Gemcitabine | Gemzar | Difluorodeoxycytidine Hydrochlorothiazide|LY-188011 | Chemotherapy - Antimetabolite 14 | Gemzar (gemcitabine) is converted in cells to difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP), which act to inhibit ribonucleoside reductase and as a deoxynucleotide analog respectively, resulting in DNA strand termination and apoptosis (NCI Drug Dictionary). |
| Nab-paclitaxel | Abraxane | ABI-007|Paclitaxel Protein-bound | Chemotherapy - Taxane 3 | Abraxane (nab-paclitaxel) is an albumin-stablized version of paclitaxel, which binds microtubules and prevents depolymerization, resulting in decreased cell motility and division (NCI Drug Dictionary). |
| VS-7375 | VS 7375|VS7375|GFH 375|GFH-375|GFH375 | KRAS G12D Inhibitor 25 | VS-7375 (GFH375) selectively inhibits KRAS G12D, which potentially results in decreased cell proliferation and inhibition of tumor growth (Cancer Res (2024) 84 (6_Supplement): 3318). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07020221 | Phase Ib/II | Carboplatin + Pembrolizumab + Pemetrexed Disodium + VS-7375 Gemcitabine + Nab-paclitaxel + VS-7375 Carboplatin + Pembrolizumab + Pemetrexed Disodium VS-7375 Gemcitabine + VS-7375 Cetuximab + VS-7375 | A Phase 1/2a Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors | Recruiting | USA | 0 |
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