Therapy Detail
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| Therapy Name | Pembrolizumab + VS-7375 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Pembrolizumab | Keytruda | MK-3475 | Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 139 | Keytruda (pembrolizumab) is an antibody against PD-1 that activates T-cell mediated anti-tumor immune response (PMID: 25977344). Keytruda (pembrolizumab) is approved in melanoma, SCLC, HNSCC, classical Hodgkin Lymphoma, PMBL, urothelial carcinoma, HCC, Merkel cell carcinoma, NMIBC, cutaneous SCC, MSI-H or dMMR or TMB high advanced solid tumors, NSCLC and CD274 (PD-L1)-positive NSCLC, esophageal SCC, cervical cancer, HNSCC, and TNBC, in combination with platnum-based chemo in NSCLC, with pemetrexed and platinum in pleural mesothelioma and non-sNSCLC with no EGFR or ALK mutations, with carboplatin and paclitaxel/nab-paclitaxel in sNSCLC, with axitinib or lenvatinib in RCC, with lenvatinib in non-MSI-H or dMMR endometrial carcinoma, with platinum and fluoropyrimidine-based chemo for esophageal or gastroesophageal carcinoma, HER2-negative gastric or GEJ adenocarcinoma, with Herceptin (trastuzumab), fluoropyrimidine- and platinum-containing chemo for CD274 (PD-L1)-positive, HER2-positive gastric or GEJ adenocarcinoma, with platinum-based chemotherapy, with or without bevacizumab, for patients with CD274 (PD-L1)-positive cervical cancer, with gemcitabine and cisplatin for biliary tract cancer, with chemoradiation for cervical cancer, with carboplatin and paclitaxel for endometrial carcinoma, with paclitaxel with or without bevacizumab for epithelial ovarian, Fallopian tube, and peritonium cancer, with Padcev for MIBC (FDA.gov). |
| VS-7375 | VS 7375|VS7375|GFH 375|GFH-375|GFH375 | KRAS G12D Inhibitor 26 | VS-7375 (GFH375) selectively inhibits KRAS G12D, which potentially results in decreased cell proliferation and inhibition of tumor growth (Cancer Res (2024) 84 (6_Supplement): 3318). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07020221 | Phase Ib/II | Carboplatin + Pembrolizumab + Pemetrexed Disodium + VS-7375 Gemcitabine + Nab-paclitaxel + VS-7375 Midazolam + Repaglinide + VS-7375 Carboplatin + Pembrolizumab + Pemetrexed Disodium VS-7375 Gemcitabine + VS-7375 Pembrolizumab + VS-7375 Cetuximab + VS-7375 Defactinib + VS-7375 | A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors | Recruiting | USA | FRA | ESP | AUS | 0 |
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