Therapy Detail
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| Therapy Name | ARV-766 + Tulmimetostat |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ARV-766 | ARV 766|ARV766|Luxdegalutamide|JSB462 | Hormone - Anti-androgens 57 | ARV-766 is a proteolysis-targeted chimera (PROTAC) that induces degradation of wild-type androgen receptor (AR) and AR ligand-binding domain mutants, which potentially results in antitumor activity (J Clin Oncol 2024 42:16_suppl, 5011). | |
| Tulmimetostat | CPI0209|CPI-0209|CPI 0209|DZR123|DZR-123|DZR 123 | EZH1 inhibitor 5 EZH2 inhibitor 20 | Tulmimetostat is a second-generation inhibitor of EZH1 and EZH2, which potentially decreases tumor cell viability and reduces tumor growth (PMID: 38833522). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07206056 | Phase Ib/II | ARV-766 + Tulmimetostat lutetium Lu 177 vipivotide tetraxetan | An Open-label Dose Escalation and Expansion, Followed by a Phase II Study of Tulmimetostat (DZR123) and JSB462 (Luxdegalutamide) in Patients With Progressive Metastatic Castrate Resistant Prostate Cancer (mCRPC) (TulmiSTAR-01) (TulmiSTAR-01) | Recruiting | USA | AUS | 2 |
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