Therapy Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Therapy Name lutetium Lu 177 vipivotide tetraxetan
Synonyms
Therapy Description

Pluvicto (lutetium Lu 177 vipivotide tetraxetan) is a radioconjugate comprising a prostate-specific membrane antigen (PSMA) inhibitor radiolabeled with Lu177, which targets PSMA expressing cells, potentially resulting in decreased tumor growth (PMID: 25883127, PMID: 26795286, PMID: 32760622). Pluvicto (lutetium Lu 177 vipivotide tetraxetan) is FDA approved for use in patients with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) who have received androgen receptor (AR) pathway inhibition and taxane-based chemotherapy (FDA.gov).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Drug Name Trade Name Synonyms Drug Classes Drug Description
lutetium Lu 177 vipivotide tetraxetan Pluvicto Lu177-PSMA-617|Vipivotide tetraxetan Lu-177 Pluvicto (lutetium Lu 177 vipivotide tetraxetan) is a radioconjugate comprising a prostate-specific membrane antigen (PSMA) inhibitor radiolabeled with Lu177, which targets PSMA expressing cells, potentially resulting in decreased tumor growth (PMID: 25883127, PMID: 26795286, PMID: 32760622). Pluvicto (lutetium Lu 177 vipivotide tetraxetan) is FDA approved for use in patients with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) who have received androgen receptor (AR) pathway inhibition and taxane-based chemotherapy (FDA.gov).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03511664 Phase III lutetium Lu 177 vipivotide tetraxetan Study of 177Lu-PSMA-617 In Metastatic Castrate-Resistant Prostate Cancer (VISION) Completed USA | NLD | GBR | FRA | DEU | CAN | BEL 3
NCT06084338 Phase II lutetium Lu 177 vipivotide tetraxetan + Testosterone lutetium Lu 177 vipivotide tetraxetan Randomized Phase II Trial of Targeted Radiation With no Castration for Mcrpc Recruiting USA 0
NCT06288113 Phase II lutetium Lu 177 vipivotide tetraxetan Re-treatment With 177Lu-PSMA-617 for the Treatment of Metastatic Castration-Resistant Prostate Cancer, RE-LuPSMA Trial Recruiting USA 0
NCT05204927 Phase III Abiraterone + Enzalutamide lutetium Lu 177 vipivotide tetraxetan Abiraterone + Prednisone Lu-177-PSMA-I&T for Metastatic Castration-Resistant Prostate Cancer Active, not recruiting USA | ITA | FRA | ESP 0
NCT04663997 Phase II Docetaxel lutetium Lu 177 vipivotide tetraxetan 177 LuPSMA-617 vs Docetaxel in Metastatic Castration Resistant and PSMA-Positive Prostate Cancer Active, not recruiting CAN 0
NCT04720157 Phase III lutetium Lu 177 vipivotide tetraxetan An International Prospective Open-label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With Soc, Versus SoC Alone, in Adult Male Patients With mHSPC (PSMAddition) Active, not recruiting USA | NLD | GBR | FRA | ESP | DEU | CAN | BEL | AUT 10
NCT03042468 Phase I lutetium Lu 177 vipivotide tetraxetan Phase I Dose-escalation Study of Fractionated 177Lu-PSMA-617 for Progressive Metastatic CRPC Active, not recruiting USA 0
NCT06526299 Phase II lutetium Lu 177 vipivotide tetraxetan Low PSMA SUV Boost (LPS-Boost): Intensified 177Lu-PSMA-617 Treatment for Patients With Metastatic Castrate-Resistant Prostate Cancer With Low PSMA Expressing Disease Not yet recruiting USA 0
NCT05849298 Phase II lutetium Lu 177 vipivotide tetraxetan Enzalutamide + lutetium Lu 177 vipivotide tetraxetan Darolutamide + lutetium Lu 177 vipivotide tetraxetan Apalutamide + lutetium Lu 177 vipivotide tetraxetan A Phase II Study of AAA617 Alone and AAA617 in Combination With ARPI in Patients With PSMA PET Scan Positive CRPC (PSMACare) Recruiting USA | NLD | ITA | FRA | ESP | CAN 5
NCT04430192 Phase Ib/II lutetium Lu 177 vipivotide tetraxetan Dosimetry, Safety and Potential Benefit of 177Lu-PSMA-617 Prior to Prostatectomy (LuTectomy) Active, not recruiting AUS 0
NCT06574880 Phase Ib/II lutetium Lu 177 vipivotide tetraxetan STereotActic Body Radiotherapy and 177Lutetium PSMA in Locally Advanced Prostate Cancer (STARLiT) Not yet recruiting USA 0
NCT04689828 Phase III lutetium Lu 177 vipivotide tetraxetan 177Lu-PSMA-617 vs. Androgen Receptor-directed Therapy in the Treatment of Progressive Metastatic Castrate Resistant Prostate Cancer Active, not recruiting USA | NLD | GBR | FRA | ESP | DEU | CAN | BEL | AUT 5
NCT05682443 Phase II lutetium Lu 177 vipivotide tetraxetan + ONC-392 lutetium Lu 177 vipivotide tetraxetan ONC-392 Plus Lutetium Lu 177 Vipivotide Tetraxetan in Patients With mCRPC (PRESERVE-006) Recruiting USA 0
NCT06200103 FDA approved lutetium Lu 177 vipivotide tetraxetan Schedule De-Escalation of 177Lu-PSMA-617 for the Treatment of Metastatic Castrate Resistant Prostate Cancer Recruiting USA 0
NCT06145633 Phase II lutetium Lu 177 vipivotide tetraxetan Vorinostat Vorinostat and 177Lu-PSMA-617 for the Treatment of PSMA-Low Metastatic Castration-Resistant Prostate Cancer Recruiting USA 0
NCT05079698 Phase I lutetium Lu 177 vipivotide tetraxetan A Study of Stereotactic Body Radiotherapy and 177Lu-PSMA-617 for the Treatment of Prostate Cancer Active, not recruiting USA 0
NCT06216249 Phase II lutetium Lu 177 vipivotide tetraxetan Evaluation of a Flexible Dosing Schedule of 177Lu-PSMA-617 for the Treatment of Metastatic Castration-Resistant Prostate Cancer Recruiting USA 0
NCT04443062 Phase II lutetium Lu 177 vipivotide tetraxetan Lutetium-177-PSMA-617 in Oligo-metastatic Hormone Sensitive Prostate Cancer (Bullseye) Recruiting NLD 1
NCT05150236 Phase II Ipilimumab + lutetium Lu 177 vipivotide tetraxetan + Nivolumab lutetium Lu 177 vipivotide tetraxetan Nivolumab 177Lu-PSMA Therapy Versus 177Lu-PSMA in Combination With Ipilimumab and Nivolumab for Men With mCRPC (EVOLUTION) (EVOLUTION) Active, not recruiting AUS 0
NCT06388369 Phase Ib/II lutetium Lu 177 vipivotide tetraxetan Ipilimumab + lutetium Lu 177 vipivotide tetraxetan Neoadjuvant Lu-PSMA Radioligand Therapy and Ipilimumab in Men With Very High-risk Prostate Cancer (NEPI) Not yet recruiting DEU 0


Additional content available in CKB BOOST