Therapy Detail
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| Therapy Name | CTD402 |
| Synonyms | |
| Therapy Description |
CTD402 comprises T-lymphocytes that have been engineered with knockout of CD7, HLA-II, and TCR, and to express a chimeric antigen receptor (CAR) that targets CD7 and contains a 4-1BB co-stimulatory domain, a CD3zeta signaling domain, and a gammaC intracellular domain, which may lead to anti-tumor activity against CD7-expressing tumor cells (HemaSphere 2025; 9 (S1):431-432). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| CTD402 | CTD 402|CTD-402 | CD7 Immune Cell Therapy 4 | CTD402 comprises T-lymphocytes that have been engineered with knockout of CD7, HLA-II, and TCR, and to express a chimeric antigen receptor (CAR) that targets CD7 and contains a 4-1BB co-stimulatory domain, a CD3zeta signaling domain, and a gammaC intracellular domain, which may lead to anti-tumor activity against CD7-expressing tumor cells (HemaSphere 2025; 9 (S1):431-432). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07070219 | Phase Ib/II | CTD402 | A Study of CTD402 in T-ALL/LBL Patients (TENACITY-01) | Recruiting | USA | 0 |
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