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Therapy Name C7R-GD2.CAR-T cells + i15.NKG2D.zeta NK cells
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
C7R-GD2.CAR-T cells IL-7 Receptor Co-expressing GD2-specific CAR T-cells C7R-GD2.CAR-T cells are autologous T-cells engineered to express a constitutively active IL7R (C7R) and a chimeric antigen receptor (CAR) targeting GD2, which may have antitumor activity against GD2-expressing tumor cells (PMID: 28830878).
i15.NKG2D.zeta NK cells i15.NKG2D.zeta-NK cells i15.NKG2D.zeta NK cells are primary natural killer (NK) cells engineered to express a chimeric receptor consisting of NKG2D linked to the the T-cell receptor zeta chain, which may lead to killing of myeloid-derived suppressor cells in the tumor microenvironment and enhanced CAR-T cell activity (PMID: 30651290).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT07211737 Phase I C7R-GD2.CAR-T cells + i15.NKG2D.zeta NK cells NKG2D.Zeta-NK Cell Conditioning With C7R.GD2.CAR-T Cells for Patients With Relapsed or Refractory Osteosarcoma or Neuroblastoma Not yet recruiting USA 0


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