Therapy Detail
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| Therapy Name | HMPL-A251 |
| Synonyms | |
| Therapy Description |
HMPL-A251 is an antibody-drug conjugate (ADC) comprising an Erbb2 (Her2) antibody conjugated to a PI3K/PIKK inhibitor, which may inhibit tumor growth (Mol Cancer Ther (2025) 24 (10_Supplement): A118). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| HMPL-A251 | HMPL A251|HMPLA251 | HER2 (ERBB2) Antibody-Drug Conjugate 36 | HMPL-A251 is an antibody-drug conjugate (ADC) comprising an Erbb2 (Her2) antibody conjugated to a PI3K/PIKK inhibitor, which may inhibit tumor growth (Mol Cancer Ther (2025) 24 (10_Supplement): A118). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07228247 | Phase Ib/II | HMPL-A251 | A Phase I/IIa Study of HMPL-A251 in Participants With Advanced or Metastatic HER2-expressing Solid Tumors | Recruiting | USA | 1 |
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