Therapy Detail
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| Therapy Name | 225Ac-PSMA-617 |
| Synonyms | |
| Therapy Description |
225Ac-PSMA-617 is a 225Ac-labeled PSMA-targeting ligand that may inhibit growth of PSMA-expressing tumors (PMID: 27390158). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| 225Ac-PSMA-617 | AAA817|[225Ac]Ac-PSMA-617|Actinium Ac 225 vipivotide tetraxetan | 225Ac-PSMA-617 is a 225Ac-labeled PSMA-targeting ligand that may inhibit growth of PSMA-expressing tumors (PMID: 27390158). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06855277 | Phase III | Cabazitaxel Docetaxel Enzalutamide 225Ac-PSMA-617 + Abiraterone 225Ac-PSMA-617 Abiraterone 225Ac-PSMA-617 + Enzalutamide | Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC (AcTFirst) | Recruiting | USA | GBR | AUS | 7 |
| NCT06780670 | Phase II | 225Ac-PSMA-617 | Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy (PSMAcTION) | Recruiting | USA | ISR | BRA | AUS | 5 |
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