Therapy Detail
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| Therapy Name | 225Ac-PSMA-617 + Abiraterone |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| 225Ac-PSMA-617 | AAA817|[225Ac]Ac-PSMA-617|Actinium Ac 225 vipivotide tetraxetan | 225Ac-PSMA-617 is a 225Ac-labeled PSMA-targeting ligand that may inhibit growth of PSMA-expressing tumors (PMID: 27390158). | ||
| Abiraterone | Zytiga | CB7630 | Hormone - Anti-androgens 57 | Zytiga (abiraterone) inhibits cytochrome P-450c17, resulting in decreased androgen synthesis (PMID: 25560485). Zytiga (abiraterone) is FDA approved for patients with metastatic castration-resistant prostate cancer (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06855277 | Phase III | Cabazitaxel Docetaxel Enzalutamide 225Ac-PSMA-617 + Abiraterone 225Ac-PSMA-617 Abiraterone 225Ac-PSMA-617 + Enzalutamide | Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC (AcTFirst) | Recruiting | USA | GBR | AUS | 7 |
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