Therapy Detail
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| Therapy Name | Darolutamide + Tulmimetostat |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Darolutamide | Nubeqa | BAY1841788|ODM-201 | Hormone - Anti-androgens 57 | Nubeqa (darolutamide) is an androgen receptor antagonist that binds to and prevents nuclear translocation of the androgen receptor, thereby inhibiting expression of genes downstream of androgen receptor signaling that regulate proliferation of prostate cancer cells (PMID: 28490267). Nubeqa (darolutamide) is FDA approved for use in patients with non-metastatic castration-resistant prostate cancer, and as monotherapy or in combination with docetaxel in patients with metastatic hormone-sensitive prostate cancer (FDA.gov). |
| Tulmimetostat | CPI0209|CPI-0209|CPI 0209|DZR123|DZR-123|DZR 123 | EZH1 inhibitor 5 EZH2 inhibitor 20 | Tulmimetostat is a second-generation inhibitor of EZH1 and EZH2, which potentially decreases tumor cell viability and reduces tumor growth (PMID: 38833522). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07190300 | Phase Ib/II | Darolutamide Abiraterone + Tulmimetostat Darolutamide + Tulmimetostat | TulmiSTAR-02: A Phase I/II Open-label Study of Tulmimetostat in Combination With Darolutamide vs. Darolutamide, and Tulmimetostat With Abiraterone in Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC) (TulmiSTAR-02) | Recruiting | USA | 1 |
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