Therapy Detail
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| Therapy Name | ALTA3263 + Cetuximab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ALTA3263 | ALTA-3263|ALTA 3263 | KRAS G12C inhibitor 36 KRAS G12D Inhibitor 25 | ALTA3263 is a an isoform-selective inhibitor of KRAS with activity against KRAS G12C, KRAS G12D, and KRAS G12V, which reduces downstream signaling and potentially decreases tumor cell viability and tumor growth (Eur J Cancer 211 (2024): 114537). | |
| Cetuximab | Erbitux | IMC-C225 | EGFR Antibody 73 | Erbitux (cetuximab) is a monoclonal antibody directed against EGFR, which inhibits signal transduction and cell proliferation (PMID: 28695301). Erbitux (cetuximab) is FDA-approved for use in head and neck squamous cell carcinoma and KRAS wild-type, EGFR-positive colorectal cancer, and in combination with Braftovi (encorafenib) with or without mFOLFOX6 in patients with metastatic colorectal cancer with BRAF V600E (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06835569 | Phase I | ALTA3263 ALTA3263 + Cetuximab | A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations | Recruiting | USA | 0 |
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