Therapy Detail
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| Therapy Name | JNJ-86974680 + Pasritamig |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| JNJ-86974680 | JNJ 86974680|JNJ86974680 | Adenosine Targeting 24 | JNJ-86974680 is an antagonist of the adenosine receptor A2AR (ADORA2A) expressed on T-lymphocytes, which may relieve adenosine-mediated immune suppression and enhance antitumor activity (Cancer Res (2025) 85 (8_Supplement_2): CT137; NCI Drug Dictionary). | |
| Pasritamig | JNJ78278343|JNJ 78278343|JNJ-78278343 | CD3 Antibody 120 | Pasritamig (JNJ-78278343) is an IgG1 bispecific antibody that targets KLK2 on tumor cells and CD3 on T-lymphocytes, which may lead to T-lymphocyte activation and killing of tumor cells expressing KLK2 (PMID: 40450573). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07319871 | Phase I | JNJ-86974680 + Pasritamig | A Study of Pasritamig (JNJ-78278343) in Combination With JNJ-86974680 for Treatment of Prostate Cancer | Recruiting | USA | 0 |
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