Therapy Detail
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| Therapy Name | Carboplatin + GSK5764227 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Carboplatin | Paraplatin | CBDCA | Chemotherapy - Platinum 7 | Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary). |
| GSK5764227 | GSK 5764227|GSK-5764227|HS-20093|HS20093|HS 20093 | CD276 Antibody 21 | GSK5764227 is an antibody-drug conjugate (ADC) comprising a monoclonal antibody targeting CD276 (B7-H3) linked to a topoisomerase I inhibitor, which may induce apoptosis and inhibit proliferation of tumor cells expressing CD276 (B7-H3) (Cancer Res (2025) 85 (8_Supplement_2): CT195, NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06551142 | Phase I | Durvalumab + GSK5764227 Cetuximab + GSK5764227 Bevacizumab + GSK5764227 GSK5764227 Cisplatin + GSK5764227 Carboplatin + GSK5764227 Atezolizumab + GSK5764227 GSK5764227 + Pembrolizumab | A Study of GSK5764227 in Participants With. Advanced Solid Tumors (EMBOLD PanTumor-101) (PanTumor-101) | Recruiting | USA | ITA | GBR | FRA | ESP | CAN | ARG | 4 |
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