Therapy Detail
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| Therapy Name | GSK5764227 + Tarlatamab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| GSK5764227 | GSK 5764227|GSK-5764227|HS-20093|HS20093|HS 20093|Risvutatug rezetecan | CD276 Antibody 25 | GSK5764227 is an antibody-drug conjugate (ADC) comprising a monoclonal antibody targeting CD276 (B7-H3) linked to a topoisomerase I inhibitor, which may induce apoptosis and inhibit proliferation of tumor cells expressing CD276 (B7-H3) (Cancer Res (2025) 85 (8_Supplement_2): CT195, NCI Drug Dictionary). | |
| Tarlatamab | Imdelltra | AMG 757|AMG757|AMG-757|tarlatamab-dlle | CD3 Antibody 125 DLL3 Antibody 10 | Imdelltra (tarlatamab) is a bispecific antibody that targets CD3 on T-cells and delta-like protein 3 (DLL3) expressed by tumor cells, which may lead to cytotoxic killing of Dll3-expressing tumor cells (PMID: 31215500). Imdelltra (tarlatamab) is FDA-approved for use in patients with extensive stage small cell lung cancer who progressed on or after platinum-based chemotherapy (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06551142 | Phase I | Durvalumab + GSK5764227 Cetuximab + GSK5764227 Bevacizumab + GSK5764227 Dostarlimab-gxly + GSK5764227 GSK5764227 GSK5764227 + Tarlatamab Atezolizumab + Dostarlimab-gxly + GSK5764227 Cisplatin + GSK5764227 Carboplatin + GSK5764227 Atezolizumab + GSK5764227 GSK5764227 + Pembrolizumab | A Study of GSK5764227 in Participants With Advanced Solid Tumors (EMBOLD) (PanTumor-101) | Recruiting | USA | ITA | ISR | GBR | FRA | ESP | CAN | ARG | 5 |
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