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| Therapy Name | Molgramostim + Pseudovax + Tislelizumab |
| Synonyms | |
| Therapy Description | |
| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Molgramostim | Macrogen | Leucomax|Molgradex|SCH 39300|SCH-39300 | Macrogen (molgramostim) is a recombinant form of human granulocyte colony-stimulating factor (G-CSF), which potentially enhances proliferation, differentiation, and activity of hematopoietic progenitor cells (NCI Drug Dictionary). | |
| Pseudovax | Pseudovax is a vaccine targeting mutant GNAS, which potentially induces antitumor immune response (PMID: 34711663). | |||
| Tislelizumab | Tevimbra | BGB-A317|tislelizumab-jsgr | Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 136 | Tevimbra (tislelizumab) is a human monoclonal antibody that targets PD-1 (PDCD1), thereby blocking the binding of PD-L1 (CD274) and potentially resulting in activation of a T-cell immune response against tumor cells (PMID: 32769013, PMID: 32561638, PMID: 32540858). Tevimbra (tislelizumab) is FDA-approved for use in patients with unresectable or metastatic esophageal squamous cell carcinoma (FDA.gov). |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07341360 | Phase I | Molgramostim + Pseudovax + Tislelizumab | Pseudovax - A Cancer Vaccine for Patients With Pseudomyxoma Peritonei (Pseudovax) | Recruiting | NOR | 0 |