Therapy Detail
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| Therapy Name | ARV-393 + Glofitamab-gxbm |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ARV-393 | ARV 393|ARV393 | BCL6 Inhibitor 6 | ARV-393 is a proteolysis targeting chimera (PROTAC) targeting BCL6, which induces degradation of BCL6 and potentially inhibits tumor growth (Cancer Res (2024) 84 (7_Supplement): ND05) | |
| Glofitamab-gxbm | Columvi | RO 7082859|RO-7082859|RO7082859 | CD20 Antibody 26 CD3 Antibody 120 | Columvi (glofitamab-gxbm) is a bispecific antibody that binds the tumor-associated antigen, MS4A1 (CD20), and CD3 on T-cells to stimulate T-cell killing of CD20-expressing tumor cells (PMID: 36507690). Columvi (glofitamab-gxbm) is FDA-approved for use in patients with relapsed or refractory diffuse large B-cell lymphoma, not otherwise specified or large B-cell lymphoma (LBCL) arising from follicular lymphoma, after two or more lines of systemic therapy (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06393738 | Phase I | ARV-393 + Glofitamab-gxbm ARV-393 | A Study of ARV-393 in Relapsed/Refractory Non-Hodgkin Lymphoma. | Recruiting | USA | ESP | DNK | CAN | 0 |
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