Therapy Detail
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| Therapy Name | GTAEXS617 + Pegylated liposomal doxorubicin |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| GTAEXS617 | GTAEXS 617|GTAEXS-617 | CDK7 Inhibitor 16 | GTAEXS617 inhibits CDK7, potentially resulting in cell cycle arrest, increased apoptosis, and reduced proliferation of tumor cells, and decreased tumor growth (Cancer Res (2022) 82 (12_Supplement): 3930). | |
| Pegylated liposomal doxorubicin | Doxil | ATI-0918|CAELYX|liposomal doxorubicin | Chemotherapy - Anthracycline 13 | Doxil (pegylated liposomal doxorubicin) comprises the anthracyline doxorubicin, which intercalates into DNA and disrupts DNA replication, encapsulated in a liposome, which improves tumor penetration and decreases toxicity (NCI Drug Dictionary), and is FDA approved for ovarian cancer, AIDS-related Kaposi's sarcoma, and multiple myeloma (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05985655 | Phase Ib/II | GTAEXS617 Capecitabine + GTAEXS617 GTAEXS617 + Pegylated liposomal doxorubicin Fulvestrant + GTAEXS617 Bevacizumab + GTAEXS617 + Paclitaxel | Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors (ELUCIDATE) | Recruiting | USA | GBR | BEL | 0 |
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