Therapy Detail
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| Therapy Name | Pegylated liposomal doxorubicin + REC-617 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Pegylated liposomal doxorubicin | Doxil | ATI-0918|CAELYX|liposomal doxorubicin | Chemotherapy - Anthracycline 13 | Doxil (pegylated liposomal doxorubicin) comprises the anthracyline doxorubicin, which intercalates into DNA and disrupts DNA replication, encapsulated in a liposome, which improves tumor penetration and decreases toxicity (NCI Drug Dictionary), and is FDA approved for ovarian cancer, AIDS-related Kaposi's sarcoma, and multiple myeloma (FDA.gov). |
| REC-617 | REC 617REC617GTAEXS 617|GTAEXS-617|GTAEXS617 | CDK7 Inhibitor 16 | REC-617 (GTAEXS617) inhibits CDK7, potentially resulting in cell cycle arrest, increased apoptosis, and reduced proliferation of tumor cells, and decreased tumor growth (Cancer Res (2022) 82 (12_Supplement): 3930, (Cancer Res (2025) 85 (8_Supplement_1): 366)). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05985655 | Phase Ib/II | REC-617 Capecitabine + REC-617 Pegylated liposomal doxorubicin + REC-617 Fulvestrant + REC-617 Bevacizumab + Paclitaxel + REC-617 | Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors (ELUCIDATE) | Recruiting | USA | GBR | BEL | 0 |
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