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Therapy Name iC9-GD2-CD28-OX40 T-cells
Synonyms
Therapy Description

iC9-GD2-CD28-OX40 T-cells comprises T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that targets GD2 and contains CD28 and OX40 costimulatory domains, along with inducible Caspase-9, which potentially induces cytotoxicity against GD2-expressing tumor cells and inhibits tumor growth (PMID: 28602436).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
iC9-GD2-CD28-OX40 T-cells iC9-GD2|iC9 GD2 CD28 OX40 T-cells iC9-GD2-CD28-OX40 T-cells comprises T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that targets GD2 and contains CD28 and OX40 costimulatory domains, along with inducible Caspase-9, which potentially induces cytotoxicity against GD2-expressing tumor cells and inhibits tumor growth (PMID: 28602436).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01822652 Phase I iC9-GD2-CD28-OX40 T-cells Cyclophosphamide + Fludarabine Pembrolizumab 3rd Generation GD-2 Chimeric Antigen Receptor and iCaspase Suicide Safety Switch, Neuroblastoma, GRAIN (GRAIN) Active, not recruiting USA 0


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